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2004
Durinovic-Bello I, Schlosser M, Riedl M, Maisel N, Rosinger S, Kalbacher H, Deeg M,
Ziegler M, Elliott J, Roep BO, Karges W, and Boehm BO.
Pro- and anti-inflammatory cytokine production by autoimmune
T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes.

Diabetologia. 2004 Mar;47(3):439-450
Weidenmaier C, Kokai-Kun JF, Kristian SA, Chanturiya T, Kalbacher H,
Gross M, Nicholson G, Neumeister B, Mond JJ, and Peschel A.
Role of teichoic acids in Staphylococcus aureus nasal colonization,
a major risk factor in nosocomial infections.

Nat Med. 2004 Mar;10(3):243-5
Lautwein A, Kraus M, Reich M, Burster T, Brandenburg J, Overkleeft HS, Schwarz G, Kammer W, Weber E, Kalbacher H, Nordheim A, and Driessen C.
Human B lymphoblastoid cells contain distinct patterns of cathepsin activity in endocytic compartments and regulate MHC class II transport in a cathepsin S-independent manner.
J Leukoc Biol. 2004 May;75(5):844-55

Fauser S, Kalbacher H, Alteheld N, Koizumi K, Krohne TU, and Joussen AM.
Pharmacokinetics and safety of intravitreally delivered etanercept.
Graefes Arch Clin Exp Ophthalmol. 2004 Jul; 242(7):582-6

Moeschel K, Beck A, Weigert C, Lammers R, Kalbacher H, Voelter W, Schleicher ED,
Haring HU, and Lehmann R.
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin receptor
substrate-1 (IRS-1) attenuates the interaction with theinsulin receptor and the
tyrosine phosphorylation of IRS-1.

J Biol Chem. 2004 Jun 11;279(24):25157-63

Burster T, Beck A, Tolosa E, Marin-Esteban V, Rotzschke O, Falk K, Lautwein A,
Reich M, Brandenburg J, Schwarz G, Wiendl H, Melms A, Lehmann R, Stevanovic S,
Kalbacher H, and Driessen C.
Cathepsin G, and not the Asparagine-Specific Endoprotease, controls the
processing of Myelin Basic Protein in Lysosomes from Human B Lymphocytes.

J Immunol. 2004 May 1;172(9):5495-5503

Van Swieten PF, Maehr R, Van Den Nieuwendijk AM, Kessler BM, Reich M, Wong CS,
Kalbacher H, Leeuwenburgh MA, Driessen C, Van Der Marel GA, Ploegh HL, and
Overkleeft HS.
Development of an isotope-coded activity-based probe for the quantitative
profiling of cysteine proteases.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3131-4

Herzog BA, Ott PA, Dittrich MT, Quast S, Karulin AY, Kalbacher H, Karges W, Tary-Lehmann M, Lehmann PV, Boehm BO, and Durinovic-Bello I.
Increased in vivo frequency of IA-2 peptide-reactive IFNgamma(+)/IL-4(-)
T cells in type 1 diabetic subjects.

J Autoimmun. 2004 Aug;23(1):45-54

Leichtle A, Rauch U, Albinus M, Benohr P, Kalbacher H, Mack AF, Veh RW,
Quast U, and Russ U.
Electrophysiological and molecular characterisation of the inward rectifier in
juxtaglomerular cells from rat kidney.

J Physiol. 2004 Oct 15;560(Pt 2):365-76

Rieg S, Garbe C, Sauer B, Kalbacher H, Schittek B.
Dermcidin is constitutively produced by eccrine sweat glands and is not induced
in epidermal cells under inflammatory skin conditions.

Br J Dermatol. 2004 Sep;151(3):534-9

Pesch UE, Fries JE, Bette S, Kalbacher H, Wissinger B, Alexander C, Kohler K.
OPA1, the Disease Gene for Autosomal Dominant Optic Atrophy, Is Specifically Expressed in Ganglion Cells and Intrinsic Neurons of the Retina.
Invest Ophthalmol Vis Sci. 2004 Nov;45(11):4217-25


2003
Durinovic-Bello I, Maisel N, Schlosser M, Kalbacher H, Deeg M, Eiermann T, Karges W,
and Boehm BO.
Relationship between T and B cell responses to proinsulin in human
type 1 diabetes.

Ann N Y Acad Sci. 2003 Nov;1005:288-94


2002
Plueger EBE, Boes M, Alfonso C, Schroeter CJ, Kalbacher H, Ploegh HL, and Driessen C.
Specific role for cathepsin S in the generation of antigenic peptides in vivo.
Eur J Immunol. 2002 Feb;32(2):467-76

Muller CA, Markovic-Lipkovski J, Klatt T, Gamper J, Schwarz G, Beck H, Deeg M,
Kalbacher H, Widmann S, Wessels JT, Becker V, Muller GA, and Flad T.
Human alpha-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences
on tumor cell proliferation.

Am J Pathol. 2002 Apr;160(4):1311-24

Durinovic-Bello I, Riedl M, Rosinger S, Maisel N, Kalbacher H, Deeg M, Schreckling HJ, Schlosser M, Ziegler M, Kuehnl P, and Boehm BO.
Th2 dominance of T helper cell response to preproinsulin in individuals with preclinical type 1 diabetes.
Ann N Y Acad Sci. 2002 Apr;958:209-13

Maier JT, Haug M, Foll JL, Beck H, Kalbacher H, Rammensee HG, and Dannecker GE.
Possible association of non-binding of HSP70 to HLA-DRB1 peptide sequences
and protection from rheumatoid arthritis.

Immunogenetics. 2002 May;54(2):67-73

Schwarz G, Boehncke WH, Braun M, Schroter CJ, Burster T, Flad T,
Dressel D, Weber E, Schmid H, and Kalbacher H.
Cathepsin S activity is detectable in human keratinocytes and is selectively upregulated upon stimulation with interferon-gamma.
J Invest Dermatol. 2002 Jul;119(1):44-9

Schmid H, Sauerbrei R, Schwarz G, Weber E, Kalbacher H, and Driessen C.
Modulation of the endosomal and lysosomal distribution of cathepsins B, L
and S in human monocytes/macrophages.

Biol Chem. 2002 Jul-Aug;383(7-8):1277-83

Lamprecht G, Heil A, Baisch S, Lin-Wu E, Yun CC, Kalbacher H, Gregor M, and Seidler U.
The down regulated in adenoma (dra) gene product binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intestinal Cl-/HCO3-exchange to Na+/H+ exchange.
Biochemistry. 2002 Oct 15;41(41):12336-42

Schwarz G, Brandenburg J, Reich M, Burster T, Driessen C, and Kalbacher H.
Characterization of legumain.
Biol Chem. 2002 Nov;383(11):1813-6

Flad T, Bogumil R, Tolson J, Schittek B, Garbe C, Deeg M, Mueller CA, and Kalbacher H.
Detection of dermcidin-derived peptides in sweat by ProteinChip technology.
J Immunol Methods. 2002 Dec 1;270(1):53-62

Lautwein A, Burster T, Lennon-Dumenil AM, Overkleeft HS, Weber E, Kalbacher H,
and Driessen C.
Inflammatory stimuli recruit cathepsin activity to late endosomal compartments in human dendritic cells.
Eur J Immunol. 2002 Dec;32(12):3348-57


2001
Peschel A, Jack RW, Otto M, Collins LV, Staubitz P, Nicholson G, Kalbacher H, Nieuwenhuizen WF, Jung G, Tarkowski A, van Kessel KP, and van Strijp JA.
Staphylococcus aureus resistance to human defensins and evasion of neutrophil killing via the novel virulence factor MprF is based on modification of membrane lipids with l-lysine.
J Exp Med. 2001 May 7;193(9):1067-76

Papini AM, Mazzanti B, Nardi E, Traggiai E, Ballerini C, Biagioli T, Kalbacher H, Beck H, Deeg M, Chelli M, Ginanneschi M, Massacesi L, and Vergelli M.
Palmitoyl derivatives of GpMBP epitopes: T-cell response and peptidases susceptibility.
J Med Chem. 2001 Oct 11;44(21):3504-10

Oertel M, Graness A, Thim L, Buhling F, Kalbacher H, and Hoffmann W.
Trefoil factor family-peptides promote migration of human bronchial epithelial cells: synergistic effect with epidermal growth factor.
Am J Respir Cell Mol Biol. 2001 Oct;25(4):418-24

Schittek B, Hipfel R, Sauer B, Bauer J, Kalbacher H, Stevanovic S, Schirle M,
Schroeder K, Blin N, Meier F, Rassner G,and Garbe C.
Dermcidin: a novel human antibiotic peptide secreted by sweat glands.
Nat Immunol. 2001 Dec;2(12):1133-7

Beck H, Schwarz G, Schroter CJ, Deeg M, Baier D, Stevanovic S, Weber E, Driessen C, and Kalbacher H.
Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro.
Eur J Immunol. 2001 Dec;31(12):3726-36

Strobel P, Helmreich M, Kalbacher H, Muller-Hermelink HK, and Marx A.
Evidence for distinct mechanisms in the shaping of the CD4 T cell repertoire in histologically distinct myasthenia gravis-associated thymomas.
Dev Immunol. 2001;8(3-4):279-90


2000
Halder TM, Bluggel M, Heinzel S, Pawelec G, Meyer HE, and Kalbacher H.
Defensins are dominant HLA-DR-associated self-peptides from
CD34(-) peripheral blood mononuclear cells of different tumor patients (plasmacytoma, chronic myeloid leukemia).

Blood. 2000 May 1;95(9):2890-6

Lippoldt A, Liebner S, Andbjer B, Kalbacher H, Wolburg H, Haller H, and
Fuxe K.
Organization of choroid plexus epithelial and endothelial cell tight junctions and regulation of claudin-1, -2 and -5 expression by protein kinase C.
Neuroreport. 2000 May 15;11(7):1427-31

Tranquill LR, Cao L, Ling NC, Kalbacher H, Martin RM, and Whitaker JN.
Enhanced T cell responsiveness to citrulline-containing myelin basic protein in multiple sclerosis patients.
Mult Scler. 2000 Aug;6(4):220-5

Virador VM, Santis C, Furumura M, Kalbacher H, and Hearing VJ.
Bioactive motifs of agouti signal protein.
Exp Cell Res. 2000 Aug 25;259(1):54-63

Liebner S, Fischmann A, Rascher G, Duffner F, Grote EH, Kalbacher H, and Wolburg H.
Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme.
Acta Neuropathol (Berl). 2000 Sep;100(3):323-31

Liebner S, Kniesel U, Kalbacher H, and Wolburg H.
Correlation of tight junction morphology with the expression of tight junction proteins in blood-brain barrier endothelial cells.
Eur J Cell Biol. 2000 Oct;79(10):707-17

Stoltze L, Schirle M, Schwarz G, Schroter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, and Schild H.
Two new proteases in the MHC class I processing pathway.
Nat Immunol. 2000 Nov;1(5):413-8

Lippoldt A, Kniesel U, Liebner S, Kalbacher H, Kirsch T, Wolburg H, and
Haller H.
Structural alterations of tight junctions are associated with loss of polarity in stroke-prone spontaneously hypertensive rat blood-brain barrier endothelial
cells.

Brain Res. 2000 Dec 8;885(2):251-61